1. Repositório Institucional - Universidade Federal de Uberlândia
  2. Instituto de Ciências Biomédicas (ICBIM)
  3. TCC - Ciências Biomédicas
Please use this identifier to cite or link to this item: https://repositorio.ufu.br/handle/123456789/39886
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dc.creatorSouza, Sara Lemes de-
dc.date.accessioned2023-12-11T17:37:01Z-
dc.date.available2023-12-11T17:37:01Z-
dc.date.issued2023-12-09-
dc.identifier.citationSOUZA, Sara Lemes de. Antimicrobial, antibiofilm, synergistic activities, toxicity in vitro and in vivo of copper(II) complexes with thiosemicarbazone against oral pathogens. 2023. 31 f . Trabalho de Conclusão de Curso (Graduação em Biomedicina) - Universidade Federal de Uberlândia, Uberlândia, 2023pt_BR
dc.identifier.urihttps://repositorio.ufu.br/handle/123456789/39886-
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Uberlândiapt_BR
dc.rightsAcesso Embargadopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectCopper complexespt_BR
dc.subjectThiosemicarbazonept_BR
dc.subjectOral pathogenspt_BR
dc.subjectAntibiofilm activitypt_BR
dc.subjectCytotoxicitypt_BR
dc.subjectC. eleganspt_BR
dc.subjectMolecular dockingpt_BR
dc.titleAntimicrobial, antibiofilm, synergistic activities, toxicity in vitro and in vivo of copper(II) complexes with thiosemicarbazone against oral pathogenspt_BR
dc.title.alternativeAtividades antimicrobiana, antibiofilme, sinérgica, toxicidade in vitro e in vivo de complexos de cobre(II) com tiossemicarbazona contra patógenos bucaispt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor1Martins, Carlos Henrique Gomes-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/8076024656192550pt_BR
dc.contributor.referee1Silva, Helisângela-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/2043644845839549pt_BR
dc.contributor.referee2Guerra, Wendell-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/8904957949852036pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/2747745806340636pt_BR
dc.description.degreenameTrabalho de Conclusão de Curso (Graduação)pt_BR
dc.description.resumoCaries represents a prevalent public health concern worldwide. This oral condition involves intricate interactions such as biofilm formation and contributes to the development of additional pathological conditions. In the pursuit of antimicrobial agents, metallic compounds have garnered significant attention because of their large biological activity, including antibacterial features. In this scenario, Copper(II) with thiosemicarbazone Shiff base encoded [CuCl(atc-Me)] (1) and [{Cu(μ-atc-Me)}2μ-SO4] (2) have shown promising antimicrobial activity as showed by previously result. To evaluate their anticariogenic potential, assays such as Minimum Inhibitory Concentration (MIC), Minimal Bactericidal Concentration (MBC), Minimum Inhibitory Concentration of Biofilm 50% (MICB50) and synergistic activity with chlorhexidine and for the first time the toxicity of thiosemicarbazone was evaluate in Caenorhabditis elegans. The lowest value of MIC was 0,78 μg/mL for Streptococcus mutans, S. mitis, S. sanguinis and S. sobrinus and MBC presented values of bactericidal activity. The synergic activity with chlorhexidine demonstrated a synergic activity for S. mutans and Enterococcus faecalis. Cytotoxic evaluation in human fibroblast cultures revealed that complexes 1 and 2 showed IC50 equivalent to 2.9 µg/mL and 4.9 µg/mL respectively, being higher than the most promising antibacterial concentrations. The toxicity in C. elegans reveals a lethal concentration that kills 50% of larvae 3x higher than MIC for complexes 1 and 2. The binding energy analyzed by molecular docking for compounds 1 and 2 revels values in a range of -4.78 to −7.79 kcal/mol, respectively. This work points towards an alternative for the cariogenic treatment, especially because of the great activity against biofilm and toxicity above what is necessary.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.courseBiomedicinapt_BR
dc.sizeorduration31pt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA::MICROBIOLOGIA APLICADApt_BR
dc.embargo.termsResultados da pesquisa serão publicados em artigopt_BR
dc.description.embargo2025-12-09-
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