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https://repositorio.ufu.br/handle/123456789/38461| ORCID: |  http://orcid.org/0000-0001-5154-8330 |
| Tipo de documento: | Trabalho de Conclusão de Curso |
| Tipo de acceso: | Acesso Aberto |
| Título: | Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer |
| Autor: | Facciolo Filho, Antonio Carlos |
| Primer orientador: | Gomes, Matheus de Souza |
| Primer coorientador: | Alves, Tamires Caixeta |
| Primer miembro de la banca: | Melo, Carolina Pereira de Souza |
| Segundo miembro de la banca: | Araújo, Carlos Bruno |
| Resumen: | Chemoradiotherapy resistance can significantly influence treatment outcomes in cervical cancer patients. Somatic variants play a crucial role in tumor development and treatment response. This study aimed to identify potentially clinically significant variants associated with chemoradiotherapy response using RNA-seq data analysis. RNA-seq data from 31 cervical cancer patients were subjected to variant calling and subsequent analysis using a machine learning decision tree algorithm. Variants within coding genes were selected based on their potential to segregate non-responder and responder patients. The selected variants were further assessed using variant impact prediction tools. We identified and investigated variants that exhibited potential to act as biomarkers for poor chemoradiotherapy response. Comprehensive analysis using variant impact prediction tools indicated that these variants may have deleterious effects on gene function. The genes harboring these variants were found to be involved in crucial cellular processes associated with cancer progression, including cell cycle regulation, proliferation, and notably, drug resistance. Our findings suggest that specific variants, namely MUC6(NM_005961.3):c.5992C>A, PABPC1(NM_002568.4):c.1255C>T, NAP1L1(NM_004537.7):c.1064_1065delinsGG, and NLRP4(NM_134444.5):c.1488_1489insT, have the potential to serve as indicators of poor chemoradiotherapy response in cervical cancer patients. |
| Palabras clave: | Cervical cancer RNA-seq Chemoradiotherapy Somatic mutations MUC6 NAP1L1 PABPC1 NLRP4 |
| Área (s) del CNPq: | CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA HUMANA E MEDICA |
| Idioma: | eng |
| País: | Brasil |
| Editora: | Universidade Federal de Uberlândia |
| Cita: | FACCIOLO FILHO, Antonio Carlos. Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer. 2023. 42 f. Trabalho de Conclusão de Curso (Graduação em Biotecnologia) – Universidade Federal de Uberlândia, Uberlândia, 2023. |
| URI: | https://repositorio.ufu.br/handle/123456789/38461 |
| Fecha de defensa: | 23-jun-2023 |
| Aparece en las colecciones: | TCC - Biotecnologia (Patos de Minas) |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| IdentificationMutationsPotentially.pdf | TCC | 1.81 MB | Adobe PDF |  Visualizar/Abrir |
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