Efeito neuroprotetor do Resveratrol sobre a memória e a sociabilidade: uma revisão

Abstract

Psychiatric disorders are a global health concern. A significant portion of the population has disorders related to memory and sociability, such as Alzheimer's Disease and Autistic Spectrum Disorder. More than 44 million people suffer from Alzheimer's disease in the world, and this disease is characterized by the progression of loss of memory and other cognitive functions. Autistic Spectrum Disorder encompasses social communication deficits as well as language delays, repetitive, restricted, and unusual sensory-motor movements. In general, Resveratrol, a natural product, is studied due to the benefits presented as reduction of neuronal damage and reduction of neurodegeneration of the cerebral cortex. Thus, due to the positive effects of Resveratrol, the objective of this work is to review studies on the effectiveness of this substance on memory and sociability. The sites used for this literature review were PubMed, SciElo and Google Scholar, with selected articles in English and Portuguese. Articles that did not focus on psychiatric disorders of memory and sociability were discarded. Resveratrol is a polyphenol that has an antioxidant, anti-inflammatory and neuroprotective effect. In patients with AD treated for 52 weeks with Resveratrol, there was a decrease in memory loss, a decrease in the clustering of Beta-amyloid peptides and the pro-inflammatory mediators TNF-α and Interleukins compared to the placebo group. Other studies have shown that Resveratrol reduced levels of Reactive Oxygen Species and improved cognitive function. Intravenous administration of the compound showed better results in targeting brain regions, while oral administration resulted in a more accelerated metabolism. Thus, more studies need to be carried out to establish the specific doses, as well as the route of administration of the substance in these diseases. In general, the use of Resveratrol shows promise for neurodegenerative diseases.