Publicação: Calomys callosus: um modelo animal experimental aplicado a investigações de doenças parasitárias de interesse de saúde pública
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CNPQ::CIENCIAS BIOLOGICAS, CNPQ::CIENCIAS DA SAUDE
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Rosa, Rafael Borges
Resumo
The appearance and spread of parasitic diseases around the world aroused the interest of
the scientific community to discover new animal models for improving the quality and specificity
of surveys. Calomys callosus is a rodent native to South America, an easy handling model, with
satisfactory longevity and reproducibility. C. callosus is susceptible to toxoplasmosis and can be used
as experimental model for the study the pathogenesis, treatment, vertical transmission, and ocular
toxoplasmosis. C. callosus can also be used to study cutaneous and visceral leishmaniasis, as the
animals present cutaneous lesions, as well as parasites in the organs. C. callosus has epidemiological
importance in Chagas disease, and since it is a Trypanosoma cruzi natural host in which rodents show
high parasitemia and lethality, they are also effective as a model of congenital transmission. In the
study of schistosomiasis, Schistosoma mansoni was proven to be a C. callosus natural host; thus, this
rodent is a great model for fibrosis, hepatic granulomatous reaction, and celloma associated with
lymphomyeloid tissue (CALT) during S. mansoni infection. In this review, we summarize the leading
studies of parasitic diseases that used C. callosus as a rodent experimental model, describing the main
uses and characteristics that led them to be considered an effective model.
Abstract
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Calomys callosus, Animal model, Parasitic diseases, Public health, Schistosoma mansoni, Toxoplasma gondii, Leishmania, Trypanosoma
Citação
TEIXEIRA, Samuel Cota. CASTRO, Emilene Ferreira de. DANTAS, Willyenne Marília. FERRO, Eloisa Amália Vieira. SILVA, Murilo Vieira da. Calomys callosus: An Experimental Animal Model Applied to Parasitic Diseases Investigations of Public Health Concern. 2022. 14 f. Trabalho de Conclusão de Curso (Graduação em Enfermagem) – Universidade Federal de Uberlândia, Uberlândia, 2023.
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