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https://repositorio.ufu.br/handle/123456789/36649| Document type: | Trabalho de Conclusão de Curso |
| Access type: | Acesso Embargado |
| Embargo Date: | 2024-08-11 |
| Title: | Calomys callosus: um modelo animal experimental aplicado a investigações de doenças parasitárias de interesse de saúde pública |
| Alternate title (s): | Calomys callosus: an experimental animal model applied to parasitic diseases investigations of public health concern |
| Author: | Teixeira, Samuel Cota Castro, Emilene Ferreira de Dantas, Willyenne Marília Ferro, Eloisa Amália Vieira Silva, Murilo Vieira da |
| First Advisor: | Costa, Mylla Spirandelli da |
| First coorientator: | Rosa, Rafael Borges |
| First member of the Committee: | França, Flávia Batista Ferreira |
| Second member of the Committee: | Coutinho, Loyane Bertagnolli |
| Summary: | The appearance and spread of parasitic diseases around the world aroused the interest of the scientific community to discover new animal models for improving the quality and specificity of surveys. Calomys callosus is a rodent native to South America, an easy handling model, with satisfactory longevity and reproducibility. C. callosus is susceptible to toxoplasmosis and can be used as experimental model for the study the pathogenesis, treatment, vertical transmission, and ocular toxoplasmosis. C. callosus can also be used to study cutaneous and visceral leishmaniasis, as the animals present cutaneous lesions, as well as parasites in the organs. C. callosus has epidemiological importance in Chagas disease, and since it is a Trypanosoma cruzi natural host in which rodents show high parasitemia and lethality, they are also effective as a model of congenital transmission. In the study of schistosomiasis, Schistosoma mansoni was proven to be a C. callosus natural host; thus, this rodent is a great model for fibrosis, hepatic granulomatous reaction, and celloma associated with lymphomyeloid tissue (CALT) during S. mansoni infection. In this review, we summarize the leading studies of parasitic diseases that used C. callosus as a rodent experimental model, describing the main uses and characteristics that led them to be considered an effective model. |
| Keywords: | Calomys callosus Animal model Parasitic diseases Public health Schistosoma mansoni Toxoplasma gondii Leishmania Trypanosoma |
| Area (s) of CNPq: | CNPQ::CIENCIAS BIOLOGICAS CNPQ::CIENCIAS DA SAUDE |
| Language: | eng |
| Country: | Brasil |
| Publisher: | Universidade Federal de Uberlândia |
| Quote: | TEIXEIRA, Samuel Cota. CASTRO, Emilene Ferreira de. DANTAS, Willyenne Marília. FERRO, Eloisa Amália Vieira. SILVA, Murilo Vieira da. Calomys callosus: An Experimental Animal Model Applied to Parasitic Diseases Investigations of Public Health Concern. 2022. 14 f. Trabalho de Conclusão de Curso (Graduação em Enfermagem) – Universidade Federal de Uberlândia, Uberlândia, 2023. |
| URI: | https://repositorio.ufu.br/handle/123456789/36649 |
| Date of defense: | 11-Aug-2022 |
| Appears in Collections: | TCC - Enfermagem |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| CalomysCallosusExperimental.pdf | 806.79 kB | Adobe PDF |  View/Open |
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