Publicação: Coordination compounds against multi-drug resistant bacteria: a critical review
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CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA, CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA
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Bergamini, Fernando Rodrigues Goulart
Resumo
In the effort to shed some light on the bacterial multiresistance problem and the lack of a dynamic approach able to overcome the drug innovation gap, coordination compounds arise as a very promissing source of potential antibacterials. Ubiquitously active against several biomolecular components of the bacterial cell, these potential therapeutics have presented low probability of resistance development . As adjuvants those compounds were shown to reverse bacterial resistance against certain antibacterial drug. Herein the readership will find both historically revelant and current developments of coordination compounds encompassing transition and post-transition metal complexes as well as metalloid-based molecules that have shown activity against resistant strains. Seeking to further stimulate drug development, pivotal information regarding virulence and resistance factors of nosocomial pathogenic bacteria can also be found as bullet statements.
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Compostos de coordenação, Coordination compounds, Bactérias, Bacteria, Resistência a múltiplos fármacos, Multi-drug resistance
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BENEDICTO, Christian Cavalini; NETO, Antônio Marçal; MENEZES, Ralciane de Paula; JARDIM, Ana Carolina Gomes; ABBEHAUSEN, Camilla; BERGAMINI, Fernando Rodrigues Goulart; MARTINS, Carlos Henrique Gomes. Coordination compounds against multi-drug resistant bacteria: a critical review. 2021. 17 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) - Universidade Federal de Uberlândia, Uberlândia, 2021.
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