Associação da terapia medicamentosa convencional e biológica na composição corporal e ângulo de fase em pacientes com Doença de Crohn

Abstract

Introduction: Crohn's disease (CD) is a chronic and inflammatory condition. Drug treatment is done through conventional therapy, which include drugs such as corticosteroids, aminosalicylates, thiopurines and methotrexate and biological therapy, with anti-TNFα agents. The main objective of this study was to analyze the association between the use of medications in body composition and phase angle (PA) in patients with CD.

Methods: A cross-sectional study was carried out with 28 outpatients with CD that used specific medication for the disease (corticosteroids, aminosalicylates, thiopurines, methotrexate and anti-TNFα agents). Body composition was mensured using bioelectrical impedance (BIA) and anthropometric measurements, such as weight, height, body mass index (BMI), arm circumference (AC), calf circumference (CC) and triceps skin fold (TSF). Results: Of the patients evaluated, about 64% were female and 60,7% were in remission phase of the disease. In addition, 53,6% of the sample used at least two drugs and 75% used anti-TNFα agents. In general, there were no significant changes in body components, such as lean mass (LM) and fat mass (FM) by drugs, except for AF, which showed a statistically significant difference between patients who used corticosteroids and those who did not (5,60 ± 0,14 vs. 6,76 ± 0,91, p < 0.001). However, there was no statistically significant differences on those who used anti-TNFα agentes (6,79 ± 0,91 vs. 6,36 ± 0,96, p = 0.298). Conclusion: In patients using corticosteroids, a significant reduction in PA was seen, unlike the group using anti-TNFα agentes, which did not seen significant differences. The body composition of patients with CD was not significantly altered by the medications.