Avaliação histopatológica de lesões cutâneas em ratos após o uso de Sthryphondentron barbatiman e Tanacetum vulgare

Abstract

The search for treatment methods through renewable sources has been the goal of numerous researches. The usage of plants also known as phytotherapy has become increasingly important in view of it already have several proven therapeutic properties. The aim was to analyze the efficiency of the phytotherapics Stryphnodentrom barbatiman and Tanacetum vulgare using the concentration of 10% of each principle in surgical wounds Rattus norvergicus skin through a comparative analysis of histological alterations. Healing is a combination of biochemical, physiological, and cellular processes that seek to restore wounded tissue or replace it with collagen. To assist in the cicatricial process, one can use herbal or chemical principles. Twenty rats were used, which were divided randomly in two groups of 10 animals each. An incisional, circular-shaped lesion was performed on the back of the animals in group I (G1). The wounds were treated with the ointment containing 10% of each extracted principle and the control group (CG) was treated with placebo ointment. The experiment lasted 11 days of treatment in rats. The wound skin samples were collected at four different moments on day 0 (D0), day 04 (D4), day 07 (D7) and day 11 (D11). The results show better healing through topical use of Stryphnodentrom barbatiman and Tanacetum vulgare at 20% in experimentally induced wounds in Rattus norvergicus.