A interferência da hidroclorotiazida no reparo de lesões ósseas induzidas em ratos Wistar

Abstract

Bone is a multifunctional, metabolically very active tissue composed of a heterogeneous population of cells at different stages of cell differentiation. It is in dynamic equilibrium, with regulation of the mobilization and mineral deposition, during the life of the individual. It is a metabolically fabric that undergoes a continuous process of renovation and remodeling. Several are the types of fractures and their etiological causes can leave and pathological to traumatic events. Thus, bone remodeling develops based on two antagonistic but coupled processes: bone formation and resorption by osteoblastic and osteoclast lines. Several evaluation techniques have been proposed for the diagnosis and follow-up of bone regeneration. For example, radiographs are used to give qualitative information about the fracture line and to observe the union of the bone fragments, or even to quantify parameters of the geometry, but it is unable to predict the stiffness of the callus. There are also options on the effect of some medications among others. Therefore, the objective of this study was to verify the performance of hydrochlorothiazide in the process of bone regeneration after tibial remarking of Wistars rats. For this, 24 female animals were used, divided into two groups containing each 12 animals: group I or control and group II or hydrochlorothiazide. These groups were subdivided into 02 subgroups of 06 animals each, analyzed at 7 and 15 days of tibial lesion performed with a surgical procedure with properly sedated animals. In summary, this study showed that hydrochlorothiazide does not favor greater formation of primary bone tissue in comparison to the control group, but it can be observed that the group treated with Hydrochlorothiazide obtained a greater maturation of secondary or permanent bone tissue in comparison to the control group.