Uso da miltefosina como terapia combinada em Leishmaniose Visceral Canina - relato de caso

Abstract

Canine visceral leishmaniasis (LVC) is a zoonotic disease caused by the protozoan Leishmania chagasi, a species similar to Leishmania infantum. LVC represents a serious public health problem, and is considered a potentially fatal disease, if not treated early and adequately. Recently, a new drug based on miltefosine (Milteforan® Virbac) has been authorized for veterinary use in the treatment of LVC. The aim of the study was to evaluate the efficacy of miltefosine as a combination therapy in the treatment protocol of this disease in a dog of approximately 2 years who was attended at the Uberlândia Federal University (UFU) veterinary hospital in Uberlândia, Minas Gerais, Brazil. The dog exhibited clinical and laboratory signs of the disease and was reactive in serological tests and positive by PCR. The animal was treated with 2 mg / kg oral miltefosine once daily (SID) for 28 days, 10 mg / kg allopurinol twice daily (BID) continuous use and 0.5 mg / kg domperidone once daily (SID) for 60 days. The animal was monitored for clinical signs and laboratory abnormalities every 30 days after initiation of treatment over a 3-month period. After 3 months it returned, for PCR-RT to quantify the parasite load. According to the clinical and laboratory findings, miltefosine as a combination therapy has been shown to be effective in the treatment of LVC.