Identificação, prevenção e tratamento da síndrome mão-pé induzida por quimioterapia: Uma revisão sistemática.

Abstract

Hand-foot syndrome is an adverse reaction experienced by several patients undergoing treatment for cancer. Although not life-threatening, it may result in reduction in dosage with shortening of intensity and duration of treatment. The objective of this study was to evaluate the scientific evidences related to the prevention and treatment of the hand-foot syndrome induced by chemotherapeutic agents and to identify the main signs and symptoms that allow the recognition of the syndrome. This is a systematic review of the literature without language restrictions, in the Medline/PubMed, Health Virtual Library and Scopus databases, including gray literature and manual search. The inclusion of the articles was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). A total of 29 articles were included in this review, including randomized controlled trials, case-control, observational studies, series and case reports. The results showed the use of cryotherapy and hydrotherapy as the main alternatives in the prevention of hand-foot syndrome. There were also satisfactory results with the use of urea cream in the prevention and treatment, and the use of pyridoxine still does not present conclusive results. Regarding the reports and case series, they refer to the reduction and / or suspension of the treatment, and presented options for the treatment of the syndrome with several therapeutic agents. The taxanes group predominated among the drugs inducing hand-foot syndrome. The study made it possible to conclude that the recognition of signs and symptoms may help prescribers to identify the hand-foot syndrome. Regarding prophylaxis and treatment, there was an empirical and controversial behavior among prescribers. However, it is worth highlighting the need for future research to elucidate the etiology and to define safe treatment protocols