Assinatura transcricional específica dos genes IL-1β, IL-6, IL-10, E TNFα em pacientes com câncer de mama

Abstract

Most of the cases of breast cancer cases are currently diagnosed in late stages. Forward to this, a growing difficulty is identified in determining the efficacy index of the applied neoplastic treatment. In this way, the objective of the study was to investigate differentiations in the transcriptional levels of inflammatory markers in patients with breast cancer, subjected or not to chemotherapy, aiming to better understand the role of inflammation in this disease and its possible influence on chemotherapy. For this, it was determined by qPCR, the transcriptional level of the inflammatory markers IL-1β, IL-6, IL-10 and TNFα, in the peripheral blood of 45 women. The results obtained indicate a significantly higher expression in the breast cancer group without chemotherapy for the IL-6, and a significantly higher concentration in the breast cancer group with chemotherapy for IL-1β. A change in transcriptional levels of IL-1β was also identified according to the variation of the tumor molecular phenotype. Thus, front of the data described in the literature, and the results obtained, it is suggested a possible association between the level of expression of interleukins 6 and 1β, with the effectiveness of chemotherapy.