Determinação simultânea de ibuprofeno e arginina por eletroforese capilar com detecção condutométrica sem contato (CE-C4D)

Abstract

In this work, capillary electrophoresis technique with contactless capacitive coupled conductivity detection (CE-C4D) was used the development of a fast method of quality control of arginine (ARG) and ibuprofen (IBU). The running background eletrolyte (BGE) H3BO3 20mmolL-1 adjusted with NaOH to pH = 8.0 was used to simultaneously determine a pharmaceutical substance containing ibuprofen (IBU) + arginine (ARG) with analysis time less than 35 seconds. The limits of detection (LQD) was 30μmolL-1 and 35μmolL-1 for ARG and IBU, respectively. Recovery values of 102% for ARG and 100.5% for IBU. The proposed method can be used in quality control of raw materials and pharmaceutical formulations having such compounds in its composition.