Associação entre o tempo de uso de terapia endócrina adjuvante com inibidores de aromatase e parâmetros de adiposidade

Abstract

Introduction: The treatment of breast cancer (CM) presents as adverse effects obesity and, indirectly, functional incapacity. Obesity may decrease the efficacy of endocrine (ET) therapy with aromatase inhibitors (AI) and functional incapacity may impact the level of physical activity, thus interfering with nutritional status. Objectives: The aims were to characterize women using endocrine therapy (ET) with aromatase inhibitors (AIs), evaluate their functional capacity (FC) and determine whether the duration of AI is related to adiposity parameters. Material and Methods: This study evaluated 89 women with breast cancer undergoing ET. The FC was evaluated through the Health Assessment Questionnaire. Patients were asked about their pre-ET body mass and physical exercise. The body mass, height and waist circumference (WC) were measured, and the BMI and waist-to-height ratio (WHtR) were calculated. Bioelectrical impedance analysis was used to calculate the fat-free mass (FFM), body fat (BF) and percentage of BF (%BF). Results: The results showed that 60.7% (n=54) of the women were overweight; 66.3% (n=59) had a very high risk for metabolic complications (WC>88 cm); 93.3% (n=83) had excess abdominal fat (WHtR>0.5); and all women (n=78) presented excess %BF. No difference was observed between pre-ET BMI and BMI during ET (p=0.513). Increased functional incapacity was found in women with increased BMI, WC, WHtR and BF (Rho=0.305, p=0.01; Rho=0.297, p=0.01; Rho=0.329, p=0.01; and Rho=0.335, p=0.01, respectively), and there was a relationship between FC and the practice of physical exercise. There was no association between the duration of AI use and BMI, WC, WHtR and BF. Conclusion: Women had anthropometric measurements and BF above the recommendations, and FC was associated with BMI, WC, WHtR and BF. We observed that the BMI did not change and the duration of AI use was not associated with adiposity parameters.