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Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability

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dc.contributor.advisor-co1Ferreira, Giulia Magalhães
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/6522135001572733pt_BR
dc.contributor.advisor1Jardim, Ana Carolina Gomes
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7960921685798643pt_BR
dc.contributor.referee1Jardim, Ana Carolina Gomes
dc.contributor.referee1Latteshttp://lattes.cnpq.br/7960921685798643pt_BR
dc.contributor.referee2Costa, Larissa Catharina
dc.contributor.referee2Latteshttp://lattes.cnpq.br/2127725221876097pt_BR
dc.contributor.referee3Souza, William Marciel de
dc.contributor.referee3Latteshttp://lattes.cnpq.br/7191168464519008pt_BR
dc.creatorMarinho, Mikaela dos Santos
dc.creatorFerreira, Giulia Magalhães
dc.creatorSantos, Igor Andrade
dc.creatorGrosche, Victoria Riquena
dc.creatorJardim, Ana Carolina Gomes
dc.creator.Latteshttp://lattes.cnpq.br/1733909024106805pt_BR
dc.date.accessioned2022-07-28T17:47:04Z
dc.date.available2022-07-28T17:47:04Z
dc.date.issued2022-06-10
dc.description.degreenameTrabalho de Conclusão de Curso (Graduação)pt_BR
dc.description.embargo2023-06-10
dc.description.resumoMayaro virus (MAYV) is the etiologic agent of Mayaro Fever, a disease characterized by dengue-like symptoms and arthralgias that can progress to a chronic condition. MAYV is phylogenetically classified into the genotypes D (widely dispersed), L (limited), and N (new), being the D the most common. Additionally, a new genotype was generated by a recombination event between L and D, resulting in the genotype L/D. There are limited epidemiological and evolutionary studies on MAYV, resulting in the difficulty in tracking the emerging potential of this virus. In this context, here we investigated the MAYV genomic variations in sequences from different regions of America, and characterized the phylogenetic relationship among virus strains. Through the analysis of 40 complete genome sequences of MAYV from the GenBank database, uploaded in South, Central, and North American Countries, the phylogenetic tree was reconstructed, showing that sequences grouped according to the genotypes L, D, and L/D. Sequences characterized as genotype D were closely related to sequences from their respective countries, suggesting that isolates may had originated from circulating lineages in the respective countries. In addition, an unidentified sequence from the United States of America grouped with the genotype D, suggesting the insertion of this genotype in the country. Furthermore, our data demonstrated that a sequence previously characterized as genotype L grouped with isolates of genotype L/D, and presented an insertion of nucleotides into the nsP3, positioned identically to the genotype L/D. These results were also corroborated by our recombination analysis, which also identified this isolate as L/D hybrid. The analysis of amino acid mutations among sequences indicated positive and negative selective pressure sites, suggesting adaptability of viral fitness. These results provide information on the epidemiological distribution and evolutionary profile of MAYV, contributing to a better understanding of genotypes circulating in the Americas, as well as the potential viral changes that may contribute to the emergence of mutation of interest or new viral genotypes.pt_BR
dc.embargo.termsO trabalho está em forma de artigo científico, contendo dados inéditos que ainda serão publicados.pt_BR
dc.identifier.citationMARINHO, Mikaela dos Santos. Epidemiological distribution and evolutionary profile of Mayaro virus in the Americas: an update into genome variability, 2022. 32 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2022.pt_BR
dc.identifier.urihttps://repositorio.ufu.br/handle/123456789/35324
dc.languageengpt_BR
dc.orcid.putcode177453270
dc.publisherUniversidade Federal de Uberlândiapt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.courseBiomedicinapt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.sizeorduration32pt_BR
dc.subjectArbovirusespt_BR
dc.subjectArbovíruspt_BR
dc.subjectBioinformaticspt_BR
dc.subjectBioinformáticapt_BR
dc.subjectGenomic variabilitypt_BR
dc.subjectVariabilidade genômicapt_BR
dc.subjectMayaro viruspt_BR
dc.subjectVírus mayaropt_BR
dc.subjectMayaro feverpt_BR
dc.subjectFebre do mayaropt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICASpt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIApt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA MOLECULAR E DE MICROORGANISMOSpt_BR
dc.titleEpidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variabilitypt_BR
dc.title.alternativeDISTRIBUIÇÃO EPIDEMIOLÓGICA E PERFIL EVOLUTIVO DO VÍRUS MAYARO NAS AMÉRICAS: UMA ATUALIZAÇÃO SOBRE A VARIABILIDADE DO GENOMApt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dspace.entity.typePublication

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