Publicação: Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability
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CNPQ::CIENCIAS BIOLOGICAS, CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA, CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA MOLECULAR E DE MICROORGANISMOS
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Ferreira, Giulia Magalhães
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Mayaro virus (MAYV) is the etiologic agent of Mayaro Fever, a disease characterized by
dengue-like symptoms and arthralgias that can progress to a chronic condition. MAYV is
phylogenetically classified into the genotypes D (widely dispersed), L (limited), and N
(new), being the D the most common. Additionally, a new genotype was generated by a
recombination event between L and D, resulting in the genotype L/D. There are limited
epidemiological and evolutionary studies on MAYV, resulting in the difficulty in tracking
the emerging potential of this virus. In this context, here we investigated the MAYV
genomic variations in sequences from different regions of America, and characterized the
phylogenetic relationship among virus strains. Through the analysis of 40 complete
genome sequences of MAYV from the GenBank database, uploaded in South, Central,
and North American Countries, the phylogenetic tree was reconstructed, showing that
sequences grouped according to the genotypes L, D, and L/D. Sequences characterized
as genotype D were closely related to sequences from their respective countries,
suggesting that isolates may had originated from circulating lineages in the respective
countries. In addition, an unidentified sequence from the United States of America
grouped with the genotype D, suggesting the insertion of this genotype in the country.
Furthermore, our data demonstrated that a sequence previously characterized as genotype
L grouped with isolates of genotype L/D, and presented an insertion of nucleotides into
the nsP3, positioned identically to the genotype L/D. These results were also corroborated
by our recombination analysis, which also identified this isolate as L/D hybrid. The
analysis of amino acid mutations among sequences indicated positive and negative
selective pressure sites, suggesting adaptability of viral fitness. These results provide
information on the epidemiological distribution and evolutionary profile of MAYV,
contributing to a better understanding of genotypes circulating in the Americas, as well
as the potential viral changes that may contribute to the emergence of mutation of interest
or new viral genotypes.
Abstract
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Arboviruses, Arbovírus, Bioinformatics, Bioinformática, Genomic variability, Variabilidade genômica, Mayaro virus, Vírus mayaro, Mayaro fever, Febre do mayaro
Citação
MARINHO, Mikaela dos Santos. Epidemiological distribution and evolutionary profile of Mayaro virus in the Americas: an update into genome variability, 2022. 32 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2022.
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