Perfil sorológico e evolução dos neonatos de mães com toxoplasmose aguda na gestação

Abstract

Introduction: Congenital Toxoplasmosis is an infectious disease that resultsfrom transplacental transfer of Toxoplasma gondii to the fetus, resulting from primary infection of the mother during pregnancy. Serological tests are the most widely used and both the diagnosis. However, these antibodies may not be present at birth and there is also the possibility of false positive results in the first days of life. The aim of this study was to evaluate the profile of mothers with serological diagnosis of toxoplasmosis during pregnancy and their children Methods: We evaluated the results of serological tests IgM and IgA of 79 pairs of mothers-infants who were diagnosed with acute toxoplasmosis during pregnancy, and its correlation with congenital toxoplasmosis diagnosis. The medical records were obtained data for clinical symptoms, diagnosis and management. Differences in continuous variables between groups were compared by t test or Mann-Whitney Sudent when appropriate. We calculated sensitivity, specificity, and positive and negative predictive values of serological tests. Data were analyzed using SPSS 20.0 P values <0.05 were considered statistically Results: The diagnosis of congenital toxoplasmosis occurred in 15% of babies, of which 5 (40%) were asymptomatic at birth. The most common symptom was chorioretinitis. The sensitivity and specificity of IgA and IgM collected from newborns were 92/92% 99/96%, respectively. When associated with negative maternal IgA were observed positive or false negative results. Conclusion: The combined detection of IgM or IgA antibodies in the neonate associated with maternal IgA, combined with clinical data, can be useful in identifying newborns with congenital toxoplasmosis