1. Repositório Institucional - Universidade Federal de Uberlândia
  2. Instituto de Ciências Biomédicas (ICBIM)
  3. TCC - Ciências Biomédicas
Please use this identifier to cite or link to this item: https://repositorio.ufu.br/handle/123456789/49395
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dc.creatorSilva, Larissa Flores Diniz-
dc.date.accessioned2026-08-10T17:50:32Z-
dc.date.available2026-08-10T17:50:32Z-
dc.date.issued2026-03-13-
dc.identifier.citationSILVA, Larissa Flores Diniz. Extratos de plantas do gênero Banisteriopsis como uma abordagem terapêutica inovadora contra o vírus chikungunya. 2026. 22 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) - Universidade Federal de Uberlândia, Uberlândia, 2026.pt_BR
dc.identifier.urihttps://repositorio.ufu.br/handle/123456789/49395-
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Uberlândiapt_BR
dc.rightsAcesso Embargadopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAntiviral agentspt_BR
dc.subjectPlant extractspt_BR
dc.subjectNatural productspt_BR
dc.subjectBanisteriopsis spp.pt_BR
dc.subjectchikungunya viruspt_BR
dc.subjectCHIKVpt_BR
dc.titleExtratos de plantas do gênero Banisteriopsis como uma abordagem terapêutica inovadora contra o vírus chikungunyapt_BR
dc.title.alternativePlant extracts from the genus Banisteriopsis as an innovative therapeutic approach against the chikungunya viruspt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor-co1Cassani, Natasha Marques-
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/7568339804522929pt_BR
dc.contributor.advisor1Jardim, Ana Carolina Gomes-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7960921685798643pt_BR
dc.contributor.referee1Menezes, Ralciane de Paula-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/9034808411886042pt_BR
dc.contributor.referee2Royer, Sabrina-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/2848812662814026pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/4855657847114324pt_BR
dc.description.degreenameTrabalho de Conclusão de Curso (Graduação)pt_BR
dc.description.resumoChikungunya virus (CHIKV) is the etiological agent of chikungunya fever, an arboviral disease characterized by symptoms that can become chronic and debilitating. Despite the significant impact of the infection, no specific antivirals are currently available against CHIKV, highlighting the need for novel therapeutic strategies. In this context, extracts from the genus Banisteriopsis, which have already been described as possessing anti-inflammatory and antioxidant activities, may represent a promising source of antiviral compounds. To date, no studies have evaluated Banisteriopsis extracts against CHIKV, making this investigation an innovative approach toward identifying new therapeutic candidates. In this study we performed a dose-response assay to assess the effective concentration of 50% (EC₅₀), cytotoxic concentration of 50% (CC₅₀), and selectivity index (SI) of three extracts from the species Banisteriopsis anisandra, Banisteriopsis argyrophylla, and Banisteriopsis stellaris on CHIKV replicative cycle, using CHIKV-nanoluc, a marked virus carrying a nanoluciferase reporter gene, to infect in Vero E6 cells. Additionally, we applied a time-of-addition assay to elucidate the mechanism of action of each extract. The results indicate that all three extracts possess strong antiviral activity, with EC₅₀ values in the low-hundreds μg/mL range, with no cytotoxicity effects. Consequently, the determined SI for these extracts were higher than 4.6, indicating a favorable antiviral profile. The inhibitory profile was observed across all viral replication stages investigated, abrogating a minimum of 87% of virus replication. In conclusion, this research highlights the potential of Banisteriopsis extracts as a novel anti-CHIKV approach.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.courseBiomedicinapt_BR
dc.sizeorduration22 (Vinte e dois)pt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICASpt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.embargo.termsII - artigos publicados em revistas científicas cujo contrato firmado com os autores apresente cláusula que impeça a disponibilização daqueles em repositórios de livre acesso.pt_BR
dc.orcid.putcode223291517-
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