Filmes bio-híbridos magnéticos para entrega transdérmica de nanopartículas de ferrita de cobalto-gadolínio com atividade antineoplásica

Abstract

Nanocomposites are promising smart drug delivery systems for cancer treatment. This work describes the innovative process of obtaining magnetic sodium alginate films with cobalt-gadolinium ferrite nanoparticles, for the transdermal melanoma treatment. Gadolinium-incorporated cobalt ferrite nanoparticles, exhibiting ferromagnetic behavior, were synthesized using the coprecipitation method. The magnetic nanoparticles were incorporated into the polymeric matrix, distributed over the entire surface. The magnetic biohybrid films showed homogeneity, flexibility, grayish color and thickness around 0.0659 μm, indicating the reproducibility of the preparation method. Magnetic saturation (Ms) was 0.22 emu/g and coercivity (Hc) 1.18 kOe. The incorporation of gadolinium ions influenced the rigidity of the membranes without compromising the magnetic capacity. The films showed significant cytotoxic activity against murine melanoma cells in in vitro tests. The in vivo nanotoxicity assay on a Drosophila melanogaster model determined that the prepared systems were biocompatible.