Pseudomonas aeruginosa resistente aos carbapenêmicos produtor de NDM-1

Abstract

Introduction: NDM-1-producing is increasingly common in new generation of multidrug-resistant bacteria. Objective and Methods: This study reports the occurrence of metallo-β-lactamase, especially NDM in Pseudomonas aeruginosa in the state of Minas Gerais, Brazil. A disc combination test used to screen isolates and Polymerase Chain Reaction was used to search for metallo-β-lactamases genes. Results: Among the 95 strains analyzed, all were resistant to carbapenems, 20% were phenotypically positive for metallo-β-lactamases, and 1% were positive for blaSPM gene and 2.1% for blaNDM. Conclusions: In Brazil, SPM carbapenemases always was predominant among P. aeruginosa clinical isolates, but not NDM. This study highlights the need to review clinical protocols, in order to contain the dissemination of this profile.