1. Repositório Institucional - Universidade Federal de Uberlândia
  2. Instituto de Ciências Biomédicas (ICBIM)
  3. TCC - Ciências Biomédicas
Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.ufu.br/handle/123456789/46209
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Campo DCValorLengua/Idioma
dc.creatord'Almeida, Júlia Amaral Vieira-
dc.date.accessioned2025-06-25T12:34:18Z-
dc.date.available2025-06-25T12:34:18Z-
dc.date.issued2025-04-29-
dc.identifier.citationD'ALMEIDA, Júlia A. V. Combatendo o vírus Zika com um complexo de cobalto(II) e uma base de Schiff derivada da amantadina: uma nova estratégia para o desenvolvimento de fármacos antivirais. 2025. 23 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2025.pt_BR
dc.identifier.urihttps://repositorio.ufu.br/handle/123456789/46209-
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo a Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo a Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorshipUFU - Universidade Federal de Uberlândiapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Uberlândiapt_BR
dc.rightsAcesso Embargadopt_BR
dc.subjectAntiviraispt_BR
dc.subjectZika viruspt_BR
dc.subjectComplexo metálicopt_BR
dc.subjectCobaltopt_BR
dc.subjectAntiviral drugspt_BR
dc.subjectMetallic complexpt_BR
dc.subjectCobaltpt_BR
dc.titleCombatendo o vírus Zika com um complexo de cobalto(II) e uma base de Schiff derivada da amantadina: uma nova estratégia para o desenvolvimento de fármacos antiviraispt_BR
dc.title.alternativeTargeting Zika virus with a cobalt(II) complex and a Schiff base derived from amantadine: a new strategy for antiviral drug developmentpt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor-co1Cassani, Natasha Marques-
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/7568339804522929pt_BR
dc.contributor.advisor1Jardim, Ana Carolina Gomes-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7960921685798643pt_BR
dc.contributor.referee1Calmon, Marillia de Freitas-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/9165601469436240pt_BR
dc.contributor.referee2Souza, Eliza Flores de-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/1530028931178097pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/2048689496168704pt_BR
dc.description.degreenameTrabalho de Conclusão de Curso (Graduação)pt_BR
dc.description.resumoZika fever is a disease caused by the Orthoflavivirus zikaense (Zika virus, ZIKV), mainly transmitted by mosquitoes from the genus Aedes. It has been previously associated with cases of microcephaly and Guillain-Barré syndrome, drawing the attention of the health authorities worldwide. However, there are no vaccines and antivirals available against ZIKV, and therefore, the search for compounds with antiviral activity is mandatory. In this context, metallodrugs have demonstrated antiviral activity against several viruses. Here we demonstrated the anti-ZIKV activity of the cobalt ion (Co) coordinated to a Schiff base derived from amantadine using salicylaldehyde (atdSali), a complex named Co-atdSali, compared to the antiviral activity of its ligands. Vero E6 cells were infected with ZIKVPE243 in the presence of compounds at non-cytotoxic concentrations for 72 hours, when virus titers were evaluated, through immunofluorescence, and cytotoxicity, through MTT assay. Results demonstrated a strong anti-ZIKV activity, with Co-atdSali reducing over 91% of ZIKV infection, whereas Co(II) and atdSali reduced 44 and 8% of ZIKV replication, respectively. Moreover, the complex presented strong dose-response inhibition of ZIKV replication, with a SI of 14.7, when compared to its ligands, Co(II) and atdSali, that presented a SI of 3.9 and 1.6, respectively. Our findings show that the coordination of Co(II) to the atdSali ligand leads to a complex with enhanced antiviral activity when compared to the free ligands indicating its usage as a template for the development of future antiviral candidate drugs against Zika fever.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.courseBiomedicinapt_BR
dc.sizeorduration23pt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIApt_BR
dc.embargo.termsIII - resultados de pesquisa cujo conteúdo seja passível de ser patenteado ou publicado em livros e capítulos;pt_BR
dc.orcid.putcode186712082-
dc.description.embargo2027-06-25-
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