Terapias adjuvantes no manejo da osteorradionecrose: uma série de casos

Abstract

Osteoradionecrosis is a chronic and serious complication of radiation therapy in patients with malignant head and neck tumors. Clinically, osteoradionecrosis can range from minimal bone exposure to severe situations with pathologic fractures. Various therapies have been used to treat ORN, including antibiotics, debridement, surgical resection, ozone therapy, and cellular growth factors. This study reports on three cases of osteoradionecrosis treated with ozone therapy, either alone or in combination with platelet-rich fibrin and surgical resection. The results highlight the benefits of these approaches as therapeutic strategies to promote tissue regeneration and wound healing. Ozone therapy has antimicrobial and regenerative properties, while platelet-rich fibrin has been associated with the promotion of angiogenesis and tissue repair, contributing significantly to improved clinical outcomes. The integration of these therapies may be considered for the management of more complex cases with the goal of optimizing clinical outcomes and promoting more effective healing.