Complexo ternário de cobre como perspectiva para o tratamento do câncer de mama triplo negativo: combinações sinérgicas e formulações lipossomais

Abstract

Breast cancer (BC) is the most common malignant neoplasm among women worldwide. Molecularly, it is classified according to the expression of estrogen (ER) and progesterone (PR) receptors and human epidermal growth factor receptor type 2 (HER2). Triple negative breast cancer (TNBC) does not present any of these markers, accounting for 20% of cases, being more aggressive, with a worse prognosis and with a high rate of recurrence and metastases. Cytotoxic chemotherapy remains the main therapeutic alternative for TNBC, which highlights the need for innovative methods. In this context, the present study aimed to develop a new nanoformulation consisting of liposomes and evaluate its effects on TNBC cells. Initially, a new copper complex associated with a ADN repair protein inhibitor showed a synergistic and selective effect on TNBC cells. In liposomes, the effects were even more evident and, in an in vivo model, it presented low toxicity. Additional studies are necessary to elucidate the mechanisms involved; however, the promising potential of nanoformulation in the control of TNBC is evident.