1. Repositório Institucional - Universidade Federal de Uberlândia
  2. Instituto de Ciências Biomédicas (ICBIM)
  3. TCC - Ciências Biomédicas
Please use this identifier to cite or link to this item: https://repositorio.ufu.br/handle/123456789/41939
Full metadata record
DC FieldValueLanguage
dc.creatorOliveira, Ana Laura Costa-
dc.creatorSantos, Igor Andrade-
dc.creatorOliveira, Igor Santos-
dc.creatorOliveira, Laiane dos Santos-
dc.creatorGuarda, Pedro Henrique de Souza-
dc.creatorAbbehausen, Camilla-
dc.date.accessioned2024-07-30T18:28:52Z-
dc.date.available2024-07-30T18:28:52Z-
dc.date.issued2024-05-06-
dc.identifier.citationOLIVEIRA, Ana Laura Costa. Compostos coordenados a ouro(I) como novos complexos metálicos contra a replicação do vírus mayaro. 2024. 28f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2024.pt_BR
dc.identifier.urihttps://repositorio.ufu.br/handle/123456789/41939-
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Uberlândiapt_BR
dc.rightsAcesso Embargadopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAntiviraispt_BR
dc.subjectAntiviralspt_BR
dc.subjectCompostos metélicospt_BR
dc.subjectMetallic compoundspt_BR
dc.subjectCompostos de ouropt_BR
dc.subjectGold compoundspt_BR
dc.subjectVírus do Mayaropt_BR
dc.subjectMayaro viruspt_BR
dc.subjectFebre do Mayaropt_BR
dc.subjectMayaro Feverpt_BR
dc.titleCompostos coordenados a ouro(i) como novos complexos metálicos contra a replicação do vírus Mayaropt_BR
dc.title.alternativeGold(i)-coordinated compounds as new metal complexes against Mayaro virus replicationpt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor-co1Santos, Igor de Andrade-
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/6589573434199212pt_BR
dc.contributor.advisor1Jardim, Ana Carolina Gomes-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7960921685798643pt_BR
dc.contributor.referee1Campos, Guilherme Rodrigues Fernandes-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/3664009323158163pt_BR
dc.contributor.referee2Ruiz, Uriel Enrique Aquino-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/1699335192062556pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/9251829114683580pt_BR
dc.description.degreenameTrabalho de Conclusão de Curso (Graduação)pt_BR
dc.description.resumoMayaro virus (MAYV) is an arbovirus responsible for Mayaro fever, a neglected emerging disease that causes hyperthermia, muscle pain, and skin rashes. Aggravatingly, the infection can develop into a chronic arthralgia and polyarthralgia. Currently, there are no vaccines or antiviral drugs for the treatment of MAYV. In this context, Gold (Au) complexes, specially Au(I)-based ones, have previously shown antiviral activity against several viruses. Here we evaluated the potential of the novel Au(I) coordinated to 1,3-bis(2,4,6-trimethylphenyl)-imidazol-2-ylidene (IMes) complexes Au(IMes)Cl, Au(IMes)Sbtz, Au(IMes)Stzn, Au(IMes)Spym and Au(IMes)2tu as antiviral candidates against MAYV in vitro. To this, Vero E6 cells were infected with MAYV-nanoluc, an infectious clone carrying the nanoluciferase reporter gene, in the presence or absence of compounds for 24 h, when virus titres were evaluated. The screened compounds presented no cytotoxic and demonstrated strong anti-MAYV activity, reducing over 76% of MAYV infection. Dose-response assay were performed, and Au(IMes)Spym and Au(IMes)2tu showed the highest selective indexes (9 and 8.9, respectively) among the tested complexes, being selected for further analysis. Antiviral effects of Au(IMes)Spym and Au(IMes)2tu on different stages of the MAYV replicative cycle were investigated, demonstrating that the compounds were able to inhibited all stages of MAYV infection, suggesting a broad spectrum potential. Our findings show that these Au(I) coordinated compounds are an interesting source of molecules for the development of future antivirals candidates against Mayaro fever.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.courseBiomedicinapt_BR
dc.sizeorduration28pt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICASpt_BR
dc.embargo.termsIrei publicar este trabalho com artigo científicopt_BR
dc.orcid.putcode164638450-
dc.description.embargo2026-05-06-
Appears in Collections:TCC - Ciências Biomédicas

Files in This Item:
File Description SizeFormat 
CompostosCoordenadosOuro.pdf
  Until 2026-05-06		Trabalho de Conclusão de Curso1.53 MBAdobe PDFView/Open    Request a copy
Show simple item record


This item is licensed under a Creative Commons License Creative Commons