Perfil gestacional em uma coorte de gestantes com lúpus eritematoso sistêmico de um hospital universitário

Abstract

Introduction: Systemic Lupus Erythematosus (SLE) preferentially affects women of reproductive age, in a ratio of 9:1. Pregnancy predisposes to disease activity, which leads to negative maternal and fetal pregnancy outcomes. Objectives: Describe the outcomes of pregnant women with SLE treated at a tertiary hospital and study the impact of disease activity and treatment during the gestational and postpartum period. Methods: 40 pregnancies were included, from 39 women, with SLE, treated at the hospital of the federal university of Uberlândia in Minas Gerais, Brazil. A six-year time series was used (database from January 2017 to May 2023) and gestational outcomes related to disease activity and use of immunomodulatory medications were evaluated. Results: The fetal loss rate was 20% and the maternal hospitalization rate was 42.5%. Disease activity was related to prematurity (p=0.009) and newborns with low weight for gestational age (p=0.033). The dose of corticosteroids was higher in the group with disease activity and was related to a reduction in gestational age at birth (p=0.019). Conclusion: Controlling the disease is essential to avoid negative pregnancy outcomes. Data from this study can contribute to the development of local protocols for managing SLE during pregnancy.