Associação de biomarcadores espectrais com parâmetros clínicos e de sobrevida para o prognóstico e predição do câncer de próstata avançado

Abstract

The lack of accuracy of the usual methods for the prognosis and prediction of advanced prostate cancer (PCa) reveals the need to search for new accurate tools that help predict clinical survival. Thus, the aim of the study was to investigate new circulating spectral blood biomarkers for the prognosis and prediction of advanced PCa using ATR-FTIR, associating them with clinical and survival parameters. Based on the statistical analysis of the second derivative of the obtained spectra, the absorbance levels at wave numbers 1541 cm-1 and 1514 cm-1, referring to the Amide II region, were able to discriminate with good precision (AUC = 0.8438) patients with worse prognosis from those with better prognosis, showing sensitivity and specificity of 100%/75% and 75%/87.5%, respectively. The present study suggests that the wave numbers 541 cm-1 and 1514 cm-1 can be used as auxiliary tools to improve clinical precision for estimating the prognosis and prediction of advanced PCa. New studies are needed to validate the presented hypothesis.