Características imunoquímicas e estruturais do IGF-1 correlacionadas a infecção do SARS-CoV-2

Abstract

Insulin-like Growth Factor 1 (IGF-1), along with its respective receptor, is a protein involved in cell growth and division, playing a role in the maintenance of numerous tissues and the regulation of metabolism. Primarily, it is produced by its precursor in the liver. Given the importance of its physiological characteristics, the emphasis of this study was to elucidate the main molecular features of IGF-1, investigate its immunochemical aspects, and its association with the immune system during COVID-19 infection, aiming to understand its involved signaling pathways. Based on the genetic and biochemical characteristics identified in silico through computational biology tools and specialized literature review, and correlated with physiological aspects in the context of COVID-19, it was possible to highlight its differential expression in organs, tissues, and cells, as well as critical regions within its structure revealing post-translational modifications with implications for regulation and potential protein disorder. This raises new perspectives on its conformation and how it may affect the interactions with transcription factors. However, it underscores the significance of basic research data derived from computational biology, which will provide a foundation for future studies with practical applications in the fields of Biological and Medical Sciences.