Preditores de mortalidade associados as infecções fúngicas em uma UTIN mineira: uma série de oito anos

Abstract

Background and objective: In developing countries, there is a significant increase in fungal infections (FI), a worrying situation, as they are associated with higher mortality and morbidity. The aim of this study was to identify risk factors for mortality from FI in a Neonatal Intensive Care Unit (NICU) and the impact of the agent causing the infection on patient outcome. Methods: Neonates admitted for more than 24 hours in the NICU and who had a FI between January 2015 and June 2022 were included. Clinical, epidemiological and microbiological data were obtained through the analysis of the medical records. Risk factors for FI were assessed using univariate and multiple logistic regression. The impact of mortality rates was calculated using the Kaplan-Meier method. Result: During the study period, thirty newborns developed a fungal infection and ten died. The risk factor associated with mortality according to the statistical analysis was weight ≤750g and protective factors were the use of antifungals for an average of days greater than 10.9. Conclusion: There were nine deaths in neonates in a period of 30 days and C. albicans was the most frequent species, showing the importance of recognizing the risk factors and the most incident etiological agents for a more accurate approach and treatment.