New in vitro therapeutic approaches of anti-activin a mimetic peptide in lung cells in cancer disease

Abstract

The lung cancer is a severe disease that affects a huge percentage of the population, and the current treatments doesn’t offer long life expectancy to the patients. Because of this we decided to explore another path in cancer disease and develop a peptide antagonist of Activin A, a molecule that is important in lung tumor, using the phage display technique. As initial experiments we did in silico and in vitro assays like cell cytotoxicity, proliferation, Wound Healing, and others to demonstrate the capacity of this peptide to work in this way. The data present results in proliferation assay in lung cell culture and in inhibition adhesion in lung cancer cell, that shown the possibility of action in specific receptor and to modify the cell capacity of migrate, invasion and adhesion, important characteristic in lung cancer cells.