O zebrafish (Danio rerio) como modelo translacional para estudos comportamentais: uma revisão sistemática integrativa

Abstract

In recent decades, a small fish Danio rerio (zebrafish), has been consolidating itself as an important model for behavioral and translational studies. The present study aimed to conduct a systematic review on the use of the model in four areas of behavioral neuroscience: 1) perception, attention, and memory; 2) social behavior; 3) abnormal behavior; 4) psychoactive substances. The results pointed that the zebrafish model has been used with success in the explored areas presenting a consistent methodological consolidation with great potential for use in behavior neuroscience. From a translation point, this model has contributed to the study of neuronal circuitry involved in many human behavioral disorders, as well to a preliminary evaluation of several pharmacological interventions.