Emprego de derivados plasmáticos na prevenção e tratamento da osteonecrose dos maxilares relacionada ao uso de medicamentos (MRONJ) - uma revisão de literatura

Abstract

The use of antiresorptive and antiangiogenic agents that act on cells responsible for bone remodeling and angiogenesis, have been important tools for the control of several pathological conditions linked to bone metabolism, as well as some of neoplastic nature. In face of the increased use of these medicines and due to the effects that these drugs have on the body, some adverse situations such as Medication-related osteonecrosis of the jaw (MRONJ), which were previously uncommon in the clinical routine, have become increasingly, and represent a challenge even for experienced professionals. The disease has an uncertain and uncontrolled development, doesn’t have a standard approach protocol, and it’s complex and varied, which opens up a range of treatment possibilities for the dentist. In this context, in the midst of so many alternatives, the search for effective ways to accelerate and maximize the healing process has found in plasma derivatives a promising path for preventing the development of the condition and reducing morbidity in the surgical management of these patients. The objective of this study was to carry out a review of the existing literature on the effectiveness and legitimacy of the use of plasma derivatives for prevention and as an adjunct in the surgical treatment of Osteonecrosis of the Jaws.