Estabilidade, solvólise e atividade citotóxica de complexos de platina(II) contendo hidrazidas

Abstract

Platinum(II) complexes have been used as antitumor agents since the end of XX century, when cisplatin and lately carboplatin were approved by FDA. Despite the great success of these compounds in clinical medicine, a series of side effects, as well as intrinsic or acquired resistance, have motivated countless research groups to search new complexes safer and more effective. In this sense, the present work reports the synthesis, characterization, solvolysis and cytotoxic activity of platinum(II) complexes of the type cis-[PtCl2(L)2] and of the type trans-[PtCl2L(DMSO)], in which L = benzhydrazide, 4-nitrobenzhydrazide, 4-(trifluoromethyl)benzhydrazide and DMSO = dimethylsulfoxide. All complexes presented solvolysis and/or isomerization in DMSO generating four identical species for a same ligand. The cis-complexes were stable in DMF, while the trans-complexes also presented solvolysis in this solvent. A relation between the behaviour of the compounds in solution and their respective cytotoxic activities were verified and some complexes presented higher activity than cisplatin and carboplatin.