Frações enriquecidas com proantocianidinas da casca do fruto da Annona crassiflora com propriedades antioxidante e antiglicante e potencial inibitório contra hidrolases glicosídicas

Abstract

The species Annona crassiflora whose fruit is popularly known as Araticum, is a member of the Annonaceae family that is found in the Brazilian Cerrado. In the araticum peel is possible to find several phenolic compounds, in particular the proanthocyanidins that are molecules known to bring benefits to human health. In the present study the ethyl acetate extract from the araticum peel was fractionated to reach a fraction enriched with proanthocyanidins. The fraction obtained was then subjected to several tests to detect antioxidant, anti glycation and the ability to inhibit glycosidic hydrolases. The results showed that the fraction presented a high antioxidant capacity, it was also able to inhibit the α-amylase and α-glycosidase enzymes and presented an ability to inhibit the glycation process. The HPLC-ESI-MS / MS analysis identified the proanthocyanidins, showing that their isolation in the ethyl acetate extract of the araticum peel was a success. The results of this study confirm that in the araticum peel are compounds that bring great benefits to human health and can be used in the form of food, supplements or in the form of pharmaceuticals, being a natural alternative to the treatment of various diseases and pathologies.