Manifestação bucal do mieloma múltiplo: relato de caso clinico

Abstract

Multiple myeloma (MM) is a hematopoietic malignant neoplasm, characterized by monoclonal proliferation of plasma cells in the bone marrow. The cause of this disease is still unknown. This work report the case of a male, 61 years-old, who developed a rapid and painless gingival nodulation. Physical examination revealed a nodular mass of approximately 2 cm in the gingiva adjacent to the second lower right pre molar. Radiographic examination confirmed the presence of extensive, radiolucent, poorly delimited intraosseous lesion. Diagnostic hypothesis considered sarcoma (osteosarcoma or lymphoma). After an incisional biopsy and pathological examination, the lesion was diagnosed as a plasmocytic neoplasia, defined as multiple myeloma after bone marrow biopsy. The patient was referred to the Cancer Hospital of Uberlândia for treatment. It was consisted in radiotherapy, and resulted in initial regression of the buccal lesion. However, the disease remitted and the patient evolved to death thereafter.This work discussesthe clinical, radiographic and histopathological aspects of multiple myeloma, besides biological behavior of this disease.