Biomarcadores inflamatórios no cordão umbilical e sangue materno na sepse neonatal

Abstract

Introduction: Neonatal sepsis is an important cause of morbidity and mortality in children, especially in very-low-birth-weight (VLBW < 1500g) preterm infants. It is extremely important to perform early diagnosis to rapid onset the treatment and improve survival, knowing the severity of evolution. Currently, the greatest challenge is to find biomarkers that would provide information to facilitate early diagnosis and predict the severity of infection and outcomes at the onset of clinical signs and symptoms. Objective: The objective of the present review was to systematically evaluate the relationship between biomarkers in umbilical cord and maternal blood for prediction of sepsis in neonates. Material and methods: Published studies that evaluated inflammatory markers in umbilical cord and maternal blood related to neonatal sepsis were reviewed in multiple databases, especially considering the diagnosis of neonatal sepsis as the outcome according to clinical signs and /or positive cultures. Results: The seven studies included in this review were performed between 1994 and 2015 and were conducted in seven different countries. Thirteen types of different biochemical markers were evaluated and only three studies found a correlation between mother’s and newborn’s markers, but they didn’t find an association with neonatal sepsis. Conclusion: Evidences do not support a relation between umbilical cord and maternal biomarkers in neonatal sepsis, but highlight the use of umbilical cord blood samples for the diagnosis of neonatal infections.