Pupilometria no diagnóstico da doença de alzheimer

Abstract

Alzheimer's Disease (AD), in its clinical exercise, because it does not yet possess accurate diagnostic markers, is conditioned to the medical evaluation to determine a main generator of the hebratic disease. This study aims to investigate the behavior and response parameter of the pupil in a group of patients with Alzheimer's disease and to correlate with another group without the clinical picture of the disease. The proposed method of research is the Dynamic Pupilometry embedded in a portable prototype, which consists of a non-invasive analysis to dynamically measure the size and other parameters of the pupil during a pupillary cycle using a PLR luminous stimulus. A biomarkers analysis is promising in this scenario, since the diagnosis of the disease, much less important, when it comes to a condition that already knows a patient's cognitive impairment, a stage that is considered no more initial. A pupilometry software analysis program was developed and embedded in the open source computing language in a very low cost portable device (minicomputer).