Estudo do polimorfismo rs4646179 do gene da enzima conversora de angiotensina 2 (ECA2) em portadores de doença arterial coronariana (DAC).

Abstract

Both environmental and genetic factors are closely linked to the onset of cardiovascular disease in our body. Such diseases are the largest cause of death and disability in the world according to the World Health Organization. Coronary artery disease (CAD) is one of these pathologies, which affects thousands of people annually. The present work summarizes the relationship between the polymorphism rs4646179, a C / T exchange, of the Angiotensin Converting Enzyme 2 (ECA2) with the ACD, and define its possible effects for future research. For this purpose, DNA samples from patients with coronary artery disease, specifically amplified by PCR, were used. The amplified products were restricted with the enzyme HpyCH4IV and then an electrophoresis was performed to identify the genotypes. No genotypic variation was found in the 90 individuals analyzed, all of them presented the CC genotype. Therefore, in the analyzed sample there is no relationship between the rs4646179 polymorphism of ACE 2 and CAD. In conclusion, the rs4646179 polymorphism has to be better analyzed in conjunction with other polymorphisms in subsequent research, and with a greater number of patients to obtain significant results.