Desenvolvimento de membranas de acetato de celulose incorporadas com aditivos funcionais para uso em Odontologia

Abstract

Based on the use of physical barrier to isolate periodontal defects of the gingival connective and epithelial tissues so that bone, periodontal ligament, and cementum can be regenerated from their own cells, it was defined the principle of guided tissue regeneration (GTR), a procedure which has been used in many clinical situations to promote periodontal and bone regeneration. Therefore, the aim of this study was to develop and characterize physical-chemical aspects of membranes of cellulose acetate used in GTR. Given the purpose of creating a new material, it became necessary to know the characteristics of existing membranes in the market, aiming to establish their properties and understand their operation compared to the materials we have produced. We prepared 4 different membranes: cellulose acetate (CA), cellulose acetate + Calcium glycerophosphate (CA + GPC), cellulose acetate + Tetracycline (CA + Tet) and cellulose acetate + Calcium glycerophosphate + Tetracycline (CA + GPC + Tet). For comparative effect, we selected two biological absorbable membranes commonly used in GTR, which are GenDerm and BioGide Perio. The characterization was made taking into account the degree of substitution (DS) of cellulose acetate, ultimate degradation time of the six membranes by spectrophotometrically, qualitative analysis of the morphology of the surfaces and their fractures by scanning electron microscopy (SEM), crystallinity index through the X-ray diffraction, wettability through the contact angle, the barrier properties (permeability to water vapor) and thermo-mechanical properties. The estimated degradation time of the membrane was 100 days. The results indicate the potential of using membrane CA, CAT, CA Ca-GP ans CA Ca- GPT in GTR