Análise de correlações entre estabilidade de membrana de eritrócitos, níveis séricos de lipídeos e variáveis hematimétricas

Abstract

CHAPTER II: The observation that the membrane fluidity must remain within a critical interval outside which the stability and functionality of the cell tends to decrease, shows that the stability, fluidity and function are related and that the measure of erythrocytes stability allows inferences about the fluidity or functionality of these cells. The test of the FOE provides three parameters to measure stability: dX, H50 and dX/H50. These parameters enable us to relate various hematological and biochemical variables with erythrocyte fluidity or functionality and, consequently, to associate these variables to the risk of disease. This study determines the biochemical and hematological variables that are directly or indirectly related to the stability of erythrocyte through those parameters and how they relate to each other, besides knowing what are the most significant variables. For this, we measured the erythrocytes stability by the FOE method and correlated them with various hematologic and biochemical variables for 71 patients. These data were treated mathematically by simple correlation and multivariate statistics. The erythrocytes stability showed a greater association with hematologic variables than the biochemical variables. The RDW stands out for their strong and significant correlation, and freedom of influences. For the biochemical variables the erythrocytes stability was more sensible to LDLC. Erythrocyte stability is significantly associated with RDW and LDL-C. Thus, the level of LDL-C is a consistent link between stability and functionality, allowing a measure of stability is more one indirect parameter for assessing the risk of vascular diseases.