Associação entre função autonômica cardíaca, inflamação e estresse oxidativo, em adolescentes obesos após tratamento multidisciplinar

Abstract

Background: Obesity is a pathological condition that causes various disorders, including changes in the cardiac autonomic behavior in inflammatory status and oxidative stress have association with morbidity and mortality, setting currently a major global public health problems. Objective: evaluate the effects of multidisciplinary therapy on heart rate variability (HRV) and the correlation of this variable with inflammatory markers and oxidative stress in obese adolescents. Methods: 55 obese adolescents aged between 15 and 19 years, divided into two groups, treatment (GT) and control (CG), were evaluated. The volunteers underwent 6 months of multidisciplinary treatment including physical training, nutrition education, medical and psychological support. Were evaluated: anthropometric measurements (body weight, BMI and WC), autonomic modulation of heart rate through the HRV indices in the time domain (mean RR, SDNN RMSSD, pNN50), inflammatory markers by adiponectin and CRP, and oxidative stress by means of CAT, SOD and TBARS. Results: Obese adolescents undergoing multidisciplinary treatment, including clinical monitoring, nutritional intervention, psychological and physical training have reduced MC, BMI and WC. In the evaluation of time domain HRV were not significantly affected. Regarding the inflammatory profile was noticed that there was a percentage reduction of 22.52% in CRP, and adiponectin concentration in the TG increased significantly (260.23%). The evaluation of oxidative stress observed that the concentration of TBARS decreased 41.77% in the GT and increased 197.93% in the GC. Regarding the antioxidant enzymes, SOD and CAT, was not noticed any statistically significant change. Conclusions: The multidisciplinary treatment benefited obese adolescents in reducing anthropometric measurements, with improvement profile anti-inflammatory, but no statistically significant changes in HRV and oxidative stress.