Publicação: Combatendo o vírus Zika com um complexo de cobalto(II) e uma base de Schiff derivada da amantadina: uma nova estratégia para o desenvolvimento de fármacos antivirais
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CNPQ::CIENCIAS DA SAUDE, CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA
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Cassani, Natasha Marques
Resumo
Zika fever is a disease caused by the Orthoflavivirus zikaense (Zika virus, ZIKV),
mainly transmitted by mosquitoes from the genus Aedes. It has been previously associated with
cases of microcephaly and Guillain-Barré syndrome, drawing the attention of the health
authorities worldwide. However, there are no vaccines and antivirals available against ZIKV,
and therefore, the search for compounds with antiviral activity is mandatory. In this context,
metallodrugs have demonstrated antiviral activity against several viruses. Here we
demonstrated the anti-ZIKV activity of the cobalt ion (Co) coordinated to a Schiff base derived
from amantadine using salicylaldehyde (atdSali), a complex named Co-atdSali, compared to
the antiviral activity of its ligands. Vero E6 cells were infected with ZIKVPE243 in the presence
of compounds at non-cytotoxic concentrations for 72 hours, when virus titers were evaluated,
through immunofluorescence, and cytotoxicity, through MTT assay. Results demonstrated a
strong anti-ZIKV activity, with Co-atdSali reducing over 91% of ZIKV infection, whereas
Co(II) and atdSali reduced 44 and 8% of ZIKV replication, respectively. Moreover, the complex
presented strong dose-response inhibition of ZIKV replication, with a SI of 14.7, when
compared to its ligands, Co(II) and atdSali, that presented a SI of 3.9 and 1.6, respectively. Our
findings show that the coordination of Co(II) to the atdSali ligand leads to a complex with
enhanced antiviral activity when compared to the free ligands indicating its usage as a template
for the development of future antiviral candidate drugs against Zika fever.
Abstract
Palavras-chave
Antivirais, Zika virus, Complexo metálico, Cobalto, Antiviral drugs, Metallic complex, Cobalt
Citação
D'ALMEIDA, Júlia A. V. Combatendo o vírus Zika com um complexo de cobalto(II) e uma base de Schiff derivada da amantadina: uma nova estratégia para o desenvolvimento de fármacos antivirais. 2025. 23 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2025.