Análise da atividade de quantum dots de carbono e nanopartículas de ouro na indução da osteogênese em linhagem de pré-osteoblastos

Abstract

Bone fractures are common at all ages and can be classified into categories such as dental fractures, trauma fractures, and fragility fractures, such as those caused by osteoporosis. Their prevalence increases with age, especially among the elderly. Therefore, developing new treatments is essential to improve recovery, reduce complications, and promote a better quality of life. Therefore, an in vitro study was proposed using a pre-osteoblast cell line derived from mouse calvaria (MC3T3-E1) to evaluate the effect of different concentrations of carbon quantum dots and gold nanoparticles on the viability, proliferation, and differentiation of these cells into mature osteoblasts. As a result, it was observed that the cytotoxicity, proliferation, and osteogenesis of MC3T3-E1 varied according to the concentration and formulation of the materials used, and the results were promising for future biomedical applications in bone regeneration.