Publicação: Carreadores lipídicos nanoestruturados à base de compostos naturais com atividade antineoplásica
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CNPQ::CIENCIAS BIOLOGICAS::GENETICA
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Bastos, Luciana Machado
Resumo
Prostate cancer (PCa) is the second most frequent malignancy in men worldwide. Essential
oils (EOs) are natural products which can act in cancer suppression by several mechanisms.
In this work, a nanotechnological approach was used to develop and evaluate the
antineoplastic effects of EOs loaded by nanostructured lipid carriers (NLCs). Three different
NLC systems composed of cinnamon, sage or thyme EOs were optimized using factorial
design (2³). The optimal formulations were characterized in terms of biophysical parameters,
structure, stability, safety and efficacy. All optimized NLC formulations exhibited excellent
structural properties and stability over a year (25 °C). They proved to be in vitro and in vivo
biocompatible. on PNT2 normal prostate cells and on chicken embryos (CE), respectively.
In PC3 PCa cells, optimized NLCs inhibited cell proliferation and migration and changed its
morphology. In CE xenograft tumor, NLCs have inhibited tumor growth and angiogenesis.
The results from this work suggested that all developed EO-based NLC formulations had
their stability improved while the biological activity remains unchanged.
Abstract
Prostate cancer (PCa) is the second most frequent malignancy in men worldwide. Essential
oils (EOs) are natural products which can act in cancer suppression by several mechanisms.
In this work, a nanotechnological approach was used to develop and evaluate the
antineoplastic effects of EOs loaded by nanostructured lipid carriers (NLCs). Three different
NLC systems composed of cinnamon, sage or thyme EOs were optimized using factorial
design (2³). The optimal formulations were characterized in terms of biophysical parameters,
structure, stability, safety and efficacy. All optimized NLC formulations exhibited excellent
structural properties and stability over a year (25 °C). They proved to be in vitro and in vivo
biocompatible. on PNT2 normal prostate cells and on chicken embryos (CE), respectively.
In PC3 PCa cells, optimized NLCs inhibited cell proliferation and migration and changed its
morphology. In CE xenograft tumor, NLCs have inhibited tumor growth and angiogenesis.
The results from this work suggested that all developed EO-based NLC formulations had
their stability improved while the biological activity remains unchanged.
Palavras-chave
Essential oil, Prostate cancer, Natural treatment, Cinnamon, Sage, Thyme, NLC
Citação
PIMENTEL, Letícia Santos. Carreadores lipídicos nanoestruturados à base de compostos naturais com atividade
antineoplásica. 2023. 72 f. Tese (Doutorado em Genética e Bioquímica) - Universidade Federal de Uberlândia, Uberlândia, 2023. DOI http://doi.org/10.14393/ufu.te.2023.7005.
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