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Antifungal and antibiofilm activity of niobium against Candida spp.: an in vitro approach

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dc.contributor.advisor-co1Santiago, Mariana Brentini
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/4900345745903520pt_BR
dc.contributor.advisor1Martins, Carlos Henrique Gomes
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/8076024656192550pt_BR
dc.contributor.referee1Menezes, Ralciane de Paula
dc.contributor.referee1Latteshttp://lattes.cnpq.br/9034808411886042pt_BR
dc.contributor.referee2Teixeira, Thaise Lara
dc.contributor.referee2Latteshttp://lattes.cnpq.br/0504811914492666pt_BR
dc.creatorSousa, Lucas Andrade
dc.date.accessioned2025-12-22T12:15:38Z
dc.date.available2025-12-22T12:15:38Z
dc.date.issued2025-11-28
dc.description.degreenameTrabalho de Conclusão de Curso (Graduação)pt_BR
dc.description.embargo2027-11-28
dc.description.resumoCandida spp. is responsible for approximately 80% of hospital fungal infections, often leading to candidemia, prolonged hospitalization, and mortality rates ranging from 40% to 60%. The growing antifungal resistance and limited therapeutic options highlight the urgent need for new approaches. In this context, new technologies and biomaterials have been investigated to combat fungal infections. Niobium emerges as a potential technological alternative for biomedical applications because of their excellent corrosion resistance, biocompatibility. This study aimed to evaluate the antifungal and antibiofilm activity of different niobium samples against Candida spp. through in vitro assays. Strains from the American Type Culture Collection (ATCC) and a clinical isolate were tested, including C. albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis, and C. auris. Seven niobium-based samples were evaluated for minimum inhibitory and fungicidal concentrations by broth microdilution and biofilm inhibition through glass slides. The results demonstrated fungicidal and antibiofilm effects against C. albicans (0.75 mg/mL and 1.5 mg/mL, respectively), C. glabrata (0.75 mg/mL) and especially against C. krusei (0.37 mg/mL and 1.5 mg/mL; with over 80% inhibition of biofilm biomass), suggesting niobium’s promising potential as a novel antifungal agent for biomedical applications.pt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo a Pesquisa do Estado de Minas Geraispt_BR
dc.embargo.termsTrabalho a ser publicado.pt_BR
dc.identifier.citationSOUSA, Lucas Andrade. Antifungal and antibiofilm activity of niobium against Candida spp.: an in vitro approach. 2025. 17 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2025.pt_BR
dc.identifier.urihttps://repositorio.ufu.br/handle/123456789/47920
dc.languageengpt_BR
dc.publisherUniversidade Federal de Uberlândiapt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.courseBiomedicinapt_BR
dc.rightsAcesso Embargadopt_BR
dc.sizeorduration17pt_BR
dc.subjectCandida spp.pt_BR
dc.subjectFungicidal activitypt_BR
dc.subjectAntibiofilmpt_BR
dc.subjectNiobiumpt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIApt_BR
dc.titleAntifungal and antibiofilm activity of niobium against Candida spp.: an in vitro approachpt_BR
dc.title.alternativeAtividade antifúngica e antibiofilme do nióbio contra Candida spp.: uma abordagem in vitropt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dspace.entity.typePublication

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TCC - Ciências Biomédicas