Impactos do Diabetes Gestacional sobre o nervo e músculo da prole

Abstract

Gestational Diabetes Mellitus (GD) is defined as any glucose intolerance during pregnancy, promoting a hyperglycemic environment that affects the developing fetus. Excess glucose can compromise neural cells that react through physiological and structural changes. In the Peripheral Nervous System of diabetics, damage may occur in the conduction of nerve impulses and in the innervated muscles. In this sense, this project studies the impairments in the sciatic nerve and anterior tibialis muscle of diabetic rat puppies. For this, rats were subjected to pharmacological pancreatic injury on the fifth day of pregnancy. After birth, the sciatic nerve and anterior tibial muscles of 7- and 30- day-old pups were collected for morphological analysis. The results were analyzed with statistics appropriate to the distribution of data. During pregnancy, mothers induced to GD showed less weight gain and hyperglycemic evolution, while the control group was normoglycemic. The puppies in the diabetic group had a lower body mass index accompanied by muscle atrophy. No inflammatory infiltrates or signs of early degeneration were observed in the sciatic nerve of these animals. However, we affirm the importance of medical monitoring and adequate treatment during pregnancy.