Interações medicamentosas potenciais da hidroxicloroquina e suas implicações para a segurança do paciente e a saúde coletiva

Abstract

Objective: To analyze the profile of potential drug interactions involving hydroxychloroquine (HCQ), considering pharmacological mechanisms, severity, therapeutic classes, and potential adverse effects, and to discuss their implications for pharmacotherapeutic safety and public health. Methodology: A descriptive documentary study using a qualitative-quantitative approach, based on secondary data from DrugBank. The identified potential interactions were categorized by severity, pharmacological mechanism, therapeutic classes, and potential adverse effects, and the findings were contextualized within the relevant scientific literature. Results: A total of 1,509 potential drug interactions involving HCQ were identified. Of these, 226 (14.98%) were classified as severe, 614 (40.69%) as moderate, 19 (1.26%) as mild, and 650 (43.07%) were of undetermined severity. Potential pharmacodynamic interactions predominated, and the main risks described included QT interval prolongation, hepatotoxicity, metabolic alterations, and an increased risk of seizures. Potential interactions were identified across various therapeutic classes, notably antibiotics, antiarrhythmics, antipsychotics, antidepressants, and antineoplastics. Conclusion: The findings highlight the wide range of potential interactions associated with HCQ and reinforce the need for individualized pharmacotherapy assessment, particularly for individuals undergoing polypharmacy and those with chronic conditions. The high proportion of records with undetermined severity also underscores the importance of clinical monitoring and the quality of information used in pharmacotherapeutic decision-making.