Relação entre horário da alimentação e consumo de ultraprocessados em mulheres sobreviventes ao câncer de mama em tratamento com inibidores de aromatase e tamoxifeno

Abstract

Breast cancer is the most prevalent malignant neoplasm among women in Brazil, and advances in diagnosis and treatment have resulted in a growing number of survivors on continuous adjuvant endocrine therapy, such as tamoxifen (TMX) and aromatase inhibitors (AI). This study aimed to evaluate the association between meal timing and ultra-processed food (UPF) consumption in 173 breast cancer survivors using TMX (n=84) or AI (n=89). Dietary intake was assessed by 24-hour dietary recall, with foods classified according to the NOVA system. Multiple linear regression models were fitted for each treatment group. Although chrononutrition patterns were similar between groups, the associations differed according to treatment. In the TMX group, later timing of the first food intake was associated with lower consumption of unprocessed or minimally processed foods and higher participation of UPF in the diet, while later timing of the last food intake and dietary midpoint were associated with higher energy intake. In the AI group, associations were concentrated on energy intake and macronutrient distribution, with no significant associations with UPF consumption. The findings reinforce the importance of incorporating chrononutrition principles into the nutritional care of breast cancer survivors.