Publicação: Synergistic effects of probiotics and lifestyle interventions on intestinal microbiota composition and clinical outcomes in obese adults
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CNPQ::CIENCIAS DA SAUDE::ENFERMAGEM
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Menezes, Ralciane
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Background and objective: Obesity is a growing global epidemic. The compo sition of the intestinal microbiota can be influenced by several factors. Studies highlight
the role of intestinal bacteria in the pathophysiology of obesity. So, the objective of this
study was to investigate whether the use of probiotics, together with healthy lifestyle
habits, contributes to weight reduction in obese individuals by analyzing the intestinal
microbiota profile. Methods: A prospective study was carried out with 45 adults with
obesity. Participants underwent guidance on healthy lifestyle habits, received a probiotic
component containing different microbiological strains and were followed for 60 days.
Clinical parameters, body composition, biochemical analysis, and intestinal microbiota
assessment were performed before and after treatment. After 60 days, it was observed
that the bacterial strains present in the probiotic were present in the patients’ intestinal
microbiota. Participants also showed improvements in physical activity, sleep quality, and
anxiety management, as well as changes in some eating habits, such as a reduction in the
consumption of processed foods and a significant increase in water intake. Results: A
reduction in BMI, fasting glucose, insulin, HOMA-IR, LDL cholesterol, and triglycerides
was observed, in addition to an increase in HDL cholesterol, improvement in bowel move ment frequency, and stool consistency. Analysis of the intestinal microbiota revealed an
increase in microbial diversity and a better balance between the bacterial phyla Firmicutes
and Bacteroidetes. Conclusions: The changes related to improving the composition of
the intestinal microbiota, dietary habits, increased physical activity, reduced anxiety, and
better sleep quality have significantly contributed to weight loss and improvements in
physiological parameters in obese individuals.
Abstract
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intestinal microbiota, probiotics, obesity, lifestyle, habits, weight loss
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XAVIER, Analicy. Synergistic effects of probiotics and lifestyle interventions on intestinal microbiota composition and clinical outcomes in obese adults. 2025. 32 f. Trabalho de Conclusão de Curso (Graduação em Enfermagem) - Universidade Federal de Uberlândia, Uberlândia, 2025.
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