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Antioxidant activity of sabicea brasiliensis and its effect on adenine nucleotides metabolism in vascular smooth muscle cells

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dc.contributor.advisor1Fürstenau, Cristina Ribas
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/6394110096506077pt_BR
dc.creatorOliveira, Douglas Souza
dc.creator.Latteshttp://lattes.cnpq.br/6365030481413989pt_BR
dc.date.accessioned2018-10-19T18:34:00Z
dc.date.available2018-10-19T18:34:00Z
dc.date.issued2017-07-20
dc.description.degreenameTrabalho de Conclusão de Curso (Graduação)pt_BR
dc.description.resumoThis study evaluated antioxidant activity of Sabicea brasiliensis root extract and fractions and it is effect on adenine nucleotide hydrolyses in vascular smooth muscle cells. Percentage of antioxidant activities of crude extract, ethyl acetate and hydro-methanolic fractions were determinate by inhibition of the DPPH and ABTS radical in comparison with BHT standard. Results for DPPH assay showed highest antioxidant activity performance for crude extract (76%), followed by ethyl acetate (46%) and hydro-methanolic (23%) fractions. These results were corroborated by ABTS assay. Total phenolic content was evaluated by Folin-Ciocalteau colorimetric method and showed a significant amount of those molecules in crude extract (140.6 ± 7.7 mg GAE.g-1), followed by ethyl acetate (67.1 ± 4.7 mg GAE.g-1) and hydro-methanolic fraction (13.5±8.2 GAE.g-1). Vascular smooth muscular cells were treated with ethyl acetate fraction at 62.5; 125; 250 and 500 μg·mL−1 and demonstrated an inhibition on ATP hydrolysis (56,65%), evidencing that the Sabicea brasiliensis can modulate purine levels in vascular tissue.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.identifier.citationOLIVEIRA, Douglas Souza. Antioxidant activity of sabicea brasiliensis and its effect on adenine nucleotides metabolism in vascular smooth muscle cells. 2017. 26 f. Trabaho de Conclusão de Curso (Graduação em Biotecnologia) - Universidade Federal de Uberlândia, Patos de Minas, 2017.pt_BR
dc.identifier.urihttps://repositorio.ufu.br/handle/123456789/22673
dc.languageengpt_BR
dc.publisherUniversidade Federal de Uberlândiapt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.courseBiotecnologiapt_BR
dc.rightsAcesso Abertopt_BR
dc.sizeorduration26pt_BR
dc.subjectSabicea brasiliensispt_BR
dc.subjectAntioxidant activitypt_BR
dc.subjectEthy acetate fractionpt_BR
dc.subjectATP hydrolysispt_BR
dc.subjectVascular smooth muscle cellspt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERALpt_BR
dc.titleAntioxidant activity of sabicea brasiliensis and its effect on adenine nucleotides metabolism in vascular smooth muscle cellspt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dspace.entity.typePublication

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TCC - Biotecnologia (Patos de Minas)