Síntese, caracterização e avaliação do potencial anti-Trypanosoma cruzi de cinco novos complexos de cobre(II) com β-dicetonas e bases heterocíclicas.

Abstract

This work describes the synthesis of five Cu(II) complexes of the type [Cu(O,O)2] and [Cu(O,O) (N,N)NO3], where O, O = 4,4,4-trifluoro-1- (2-furyl) -1,3-butanedione (TFA) or 2-thenoyltrifluoroacetone (TTA) and N, N = 4,4-dimethoxy-2,2-bipyridine (dmb), 5-nitro-1,10-phenanthroline (nphen), 2,2-dipyridylamine (dpmaH). All complexes were characterized by elemental analysis, conductimetric, UV-Vis and IV. The spectroscopic results indicate that the copper ion coordinates to the β-diketone via oxygen atoms and to the N, N-donor ligand through the nitrogen atoms. The crystalline structure of the complexes I and II was determined by X-ray diffraction confirming the structure square planar and distorted square base pyramid, respectively. Complexes I and III and their respective ligands were evaluated against the amastigote form of the T. cruzi infectious CL Brener strain and L929 cells. The complexes exhibited good trypanocidal activity with IC 50 values around 6 μM. However, selectivity index values denote generic toxicity.