Tumor odontogênico epitelial calcificante múltiplo: caso clínico e revisão sistemática

Abstract

The Calcifying Epithelial Odontogenic Tumor (CEOT), known by the eponymous Pindborg’s Tumor, is a benign, extremely rare, locally invasive neoplasm affecting up to 3% of odontogenic tumors. Usually tumors manifest as single, intraosseous lesions in patients between the 4th and 6th decades of life. Rarely, this neoplasia is expressed as multiple lesions. In the present study, an unusual case of synchronic manifestation of intraosseous (mandibular) and bilateral peripheral (maxillary) CEOT was reported, affecting a 26-year-old male patient. Peripheral lesions were treated by excision and bone curettage; in the mandibular lesion, marginal resection with segmental osteotomy was performed. After 72 months of follow-up, no complications were identified. A sistematic review of multiple CEOT cases was performed from PubMed database, from which five cases were identified with synchronous lesions composed of peripheral or intraosseous variants. It was not possible to identify clinicopathological differences and biological behavior in these disease, compared to what has been reported for this manifesting isolated lesions.